COVID-19 patients more likely to develop gastrointestinal disorders

COVID-19 is associated with an improved threat of establishing very long-time period gastrointestinal diseases, such as irritable bowel syndrome. This is what has been shown by a investigation revealed in the journal Gut, carried out by scholars of the University of Bologna and the IRCCS AOU S.Orsola Bologna.


The info we collected display that people who have contracted COVID-19 encounter gastrointestinal signs or symptoms far more usually than people who have not been influenced by it. Given the wide distribute of COVID-19 globally, we should really for that reason count on an maximize in diagnoses related to intestine-brain conversation ailments.”


Giovanni Barbara, comprehensive professor at the Department of Healthcare and Surgical Sciences, College of Bologna and coordinator of the study


It is well recognized that viral infections can affect the gastrointestinal system and specially advertise the advancement of irritable bowel syndrome. This situation tends to be persistent, characterised by a range of intestinal problems influencing the colon, like altered bowel motility, bloating, and stomach cramping. Right up until now, nevertheless, it was unclear irrespective of whether coronavirus infection could also direct to these consequences.

The researchers then executed a possible survey with the intention of evaluating the prevalence of gastrointestinal symptoms and gut-mind conversation ailments in clients hospitalized for SARS-CoV-2 an infection. The research involved 2183 clients hospitalized in 36 amenities in 14 international locations: Italy, Bangladesh, Cyprus, Egypt, Israel, India, Macedonia, Malaysia, Romania, Russian Federation, Serbia, Spain, Sweden, and Turkey. People who had contracted COVID-19 ended up evaluated upon admission to the medical center and then adopted up for the future 12 months, evaluating their problem with that of sufferers not contaminated with the coronavirus.

The information gathered and evaluation carried out by the students therefore confirmed that clients hospitalized for COVID-19 much more commonly described the presence of gastrointestinal symptoms (59.3{2c3a8711102f73ee058d83c6a8025dc7f37722aad075054eaafcf582b93871a0}) than the control group (39.7{2c3a8711102f73ee058d83c6a8025dc7f37722aad075054eaafcf582b93871a0}). And new diagnoses of irritable bowel syndrome also emerged more usually, which were located to be related with the coexistence of allergies, breathing difficulties all through hospitalization for COVID-19, and persistent ingestion of proton pump inhibitors (gastroprotectant prescription drugs that block acid output in the stomach). In addition, at 6 months and 12 months following hospitalization, better degrees of nervousness and despair were reported among the those people who had COVID-19.

“We know that the SARS-CoV-2 virus can also infect the gastrointestinal tract, and this confirms the likelihood that COVID-19 can guide to the enhancement of irritable bowel syndrome,” describes Giovanni Marasco, a researcher at the Office of Healthcare and Surgical Sciences at the College of Bologna and 1st creator of the examine. “Traces of the coronavirus were being certainly located in the small intestine even six months following infection: this potential customers us to think that the extended point out of inflammation and activation of the immune process may well guide to the development of the gastrointestinal signs that have been noticed.”

The examine was posted in the journal Intestine below the title “Submit COVID-19 irritable bowel syndrome.” Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, and Giovanni Barbara participated for the University of Bologna and IRCCS AOU S.Orsola Bologna.


Journal reference:

Marasco, G., et al. (2022). Publish COVID-19 irritable bowel syndrome. Gut.