Atropine drops after glaucoma surgery may impair vision, prolong rehabilitation

The success of an global analyze confirmed that visible high quality lowered postoperatively in all people.

An intercontinental staff of scientists noted that atropine instillation really should be discouraged as a conventional therapy just after trabeculectomy for the reason that of the resultant better and lengthier lasting reduction in visual quality.1

Panagiotis Laspas, MD, from the Section of Ophthalmology, University Health care Centre, Johannes Gutenberg-University Mainz, Mainz, Germany, was the guide study writer.

The investigators explained that atropine has cycloplegic and mydriatic qualities, the latter of which that can trigger multiple visible aspect effects,2 which include disrupted accommodation, blurred vision, haloes, and gentle sensitivity. The probable systemic absorption of the drug ca influence the cardiovascular procedure,3 leading to dysrhythmias, and have an impact on patients’ psychological condition, causing confusion, restlessness, and psychological lability.4

They done a possible randomized review of 40 individuals who underwent normal trabeculectomy with mitomycin C at the Office of Ophthalmology Division, University Health care Center of Mainz. Postoperatively, all individuals acquired ofloxacin and dexamethasone eye drops.

The patients then had been randomly assigned into 2 teams of 20 sufferers every single 1 group (the intervention team) also been given atropine eye drops postoperatively and have been instructed to instill the drops 3 instances every day for 2 times to stabilize the anterior chamber. All patients finished a visual excellent questionnaire preoperatively and 2 and 6 weeks postoperatively.

The success confirmed that visible high quality diminished postoperatively in all individuals.

“Patients who obtained atropine eye drops described a bigger and longer-long lasting reduction in visual good quality than these who did not acquire atropine eye drops,” the authors wrote. “Trabeculectomy frequently potential customers to a transient reduction in visible excellent. This reduction was increased in severity and duration in individuals who been given postoperative atropine eye drops.”

Based on the results, the investigators recommended that “unless there is an underlying healthcare requirement, we would discourage the software of atropine as a conventional therapy for trabeculectomy surgical procedures.”


1 Laspas P, Maier E, Schuster A, et al. Consequences of postoperative atropine eye drops on visual high quality in patients going through trabeculectomy. J Clin Med. 202312:763

2 Joachimsen L, Farassat N, Bleul T, et al. Facet effects of topical atropine .05{2c3a8711102f73ee058d83c6a8025dc7f37722aad075054eaafcf582b93871a0} in comparison to .01{2c3a8711102f73ee058d83c6a8025dc7f37722aad075054eaafcf582b93871a0} for myopia control in German school little ones: A pilot analyze. Int Ophthalmol. 202141:2001–8.

3 Merli GJ, Weitz H, Martin JH, et al. Cardiac dysrhythmias linked with ophthalmic atropine. Arch Intern Med. 1986146:45–7.

4 Jimenez-Jimenez FJ, Alonso-Navarro H, Fernandez-Diaz A, et al. Neurotoxic effects induced by the topical administration of cycloplegics. A scenario report and evaluate of the literature. Rev Neurol. 200643:603–9.